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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 373M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 13
Average PDX Generation Time (days +/- SEM) 78 ± 7
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 373M
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
373M FANCD2 -0.747 1.192 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M RAF1 -0.747 1.192 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M SETD2 -0.760 1.181 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M PIK3R1 -1.633 0.645 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M RB1 -1.622 0.650 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M CDH1 -0.838 1.119 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M ZFHX3 -0.838 1.119 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M FANCA -0.838 1.119 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M TP53 -1.190 0.876 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M MYC 0.559 2.947 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M SMAD2 0.889 3.703 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 373M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Mixed Adeno & Neuro
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 373
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 373M
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
373M RB1 19 1.0 Missense variant,splice region variant '15/27 . 33 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M TP53 119 0.97 Missense variant '8/11 0 28.8 Conflicting interpretations of pathogenicity Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MAP3K1 62 0.71 Inframe insertion '1/20 0 . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MAP2K2 143 0.59 Missense variant '9/11 . 22 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M ABL1 497 0.51 Missense variant '11/11 0.00013 28.6 Not provided Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M ADAMTS7 68 0.44 Missense variant '7/24 . 26.3 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MYO5A 254 0.35 Missense variant '15/41 6.50E-05 24.4 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M SOS1 196 0.3 Missense variant '4/24 0.000114 32 Uncertain significance Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M XPO1 200 0.3 Missense variant '15/25 4.47E-06 34 Likely pathogenic Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M SMO 482 0.28 Missense variant '3/12 0.000111 28.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500