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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 424M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 6
Average PDX Generation Time (days +/- SEM) 136 ± 38
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 424M
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
424M CDKN1B -1.590 0.664 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M PTEN -23.821 1.350e-07 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M AR 4.638 24.898 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M FANCD2 0.522 2.872 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M RAF1 0.522 2.872 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M MET 0.689 3.225 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M BRAF 0.676 3.196 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M EZH2 0.676 3.196 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M CHD7 0.979 3.943 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M MYC 1.274 4.838 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
424M GNAS 0.536 2.900 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 424M
Sample Site Lymph node
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, zoladex and cosudex

Patient Information

Patient Number 424
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 424M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
424M TP53 395 0.67 Missense variant '8/11 1.63E-05 24 Pathogenic/likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
424M PIK3CA 322 0.62 Missense variant '10/21 0 27.5 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
424M ARID4A 273 0.52 Missense variant '21/24 . 29.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
424M TP53 366 0.28 Missense variant '7/11 . 23.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500