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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 330M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 18
Average PDX Generation Time (days +/- SEM) 90 ± 9
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 330M
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
330M AR 4.355 20.468 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M SETDB1 1.798 6.957 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M EZH2 0.884 3.691 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M MET 0.840 3.581 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M PIK3CA 0.834 3.564 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M PIK3CB 0.798 3.477 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M EZH2 0.774 3.420 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M BRAF 0.735 3.328 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M PIK3R2 0.723 3.302 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M PIK3CB 0.608 3.049 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M KEAP1 -0.740 1.197 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M CDH1 -0.795 1.153 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M TP53 -0.802 1.147 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M PALB2 -0.806 1.144 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M KEAP1 -0.975 1.017 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M KMT2C -1.395 0.761 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
330M CDKN1B -1.511 0.702 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 330M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 330
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 330M
Patient Age (binned in 5 year age groups) 55-59
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
330M TP53 200 0.99 Splice acceptor variant . . 24.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M RB1 197 0.99 Stop gained '20/27 . 43 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M MAG 377 0.66 Missense variant '4/11 4.08E-06 25.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M VPS13B 316 0.6 Stop gained '20/62 . 39 Pathogenic/likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M RET 499 0.47 Missense variant '11/20 . 22.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M MEN1 230 0.4 Missense variant '2/10 . 22.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M LTBP4 601 0.32 Missense variant '34/34 0.0003721 27.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M MAST4 252 0.29 Splice donor variant . . 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
330M XIRP2 428 0.29 Missense variant '9/11 . 25.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500