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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 422M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 11
Average PDX Generation Time (days +/- SEM) 62 ± 4
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 422M
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
422M AKT1 0.935 3.823 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M CHD7 0.890 3.708 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M CCND1 0.540 2.907 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M IGF2R 0.499 2.826 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M AR 1.441 2.714 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M KDM6A 1.044 2.062 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M ZNRF3 -0.783 1.163 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M PIK3R1 -1.218 0.860 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M ZFHX3 -1.249 0.842 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M SMAD2 -1.421 0.747 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M MBD1 -1.421 0.747 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M FANCA -1.422 0.747 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M PIK3R1 -1.426 0.745 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M CHD1 -1.569 0.674 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M FANCA -1.602 0.659 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M CDH1 -1.645 0.639 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
422M MGA -1.646 0.639 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 422M
Sample Site Brain
Sample source Surgery
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 422
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 422M
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
422M TP53 204 1.0 Splice donor variant . . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
422M MGA 158 0.91 Frameshift variant '16/24 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
422M IGF1R 239 0.5 Missense variant '19/21 2.03E-05 32 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
422M CTNNB1 491 0.37 Missense variant '3/15 . 25.7 Conflicting interpretations of pathogenicity, other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500