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PDX ID	424M
Host Strain(and Source)	NSG Source: Monash University
Host Strain Immune system Humanized	NO
Host Type	Testosterone supplemented
Graft Site	Subcutaneous
Current Generation (* indicates number of generations grown in Castrate host)	6
Average PDX Generation Time (days +/- SEM)	136 ± 38
Tumour preparation	Tumor solid
Tumour Characterization Technology	Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin	Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed	Routine QA every 2-3 passages
Associated meta data
PDX model availability	Yes (fixed, frozen)
Governance restriction for distribution	Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID	34413304

This heatmap displays the call type of curated CNVs in the presented samples.

This heatmap displays the call type of CNVs in commonly occurred samples.

This table displays curated CNVs

PDX ID	Gene Symbol	CNV Log2	CNV Copy	CNV Call	Experiments name	Platform	Reference genome
424M	AR	4.638	24.898	Gain-High	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	MYC	1.274	4.838	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	CHD7	0.979	3.943	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	MET	0.689	3.225	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	BRAF	0.676	3.196	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	EZH2	0.676	3.196	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	GNAS	0.536	2.900	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	FANCD2	0.522	2.872	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	RAF1	0.522	2.872	Gain	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	CDKN1B	-1.590	0.664	Loss	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19
424M	PTEN	-23.821	1.350e-07	Homdel	MURAL Prostate Cancer PDX collection	Targeted Twist Panel	hg19

Sample Number	424M
Sample Site	Lymph node
Sample source	Biopsy
Pathology Tumour Diagnosis	None
Gleason Score	None
Primary Gleason Score	None
Secondary Gleason Score	None
Tertiary Gleason Score	None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc)	0.0
Treatment Prior to Specimen Collection	ADT, zoladex and cosudex

Patient Number	424
Sex	Male
Diagnosis	Prostate Cancer
PSA at diagnosis (ng/mL)	NA
Consent to share data	Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID	424M
Patient Age (binned in 5 year age groups)	75-79

This heatmap displays the mutations of curated sequence variants.

This table displays curated sequence variants

PDX ID	Gene Symbol	Total Read Depth	Alternate Frequency	Consequence	Exon	GnomAD AF	CADD PHRED score	ClinVar significance	Platform	Experiments Name	Reference	Library Type	Instrument Type
424M	TP53	395	0.67	Missense variant	'8/11	1.63E-05	24	Pathogenic/likely pathogenic	Targeted Twist Panel	MURAL Prostate Cancer PDX collection	hg19	paired	NextSeq 500
424M	PIK3CA	322	0.62	Missense variant	'10/21	0	27.5	Pathogenic	Targeted Twist Panel	MURAL Prostate Cancer PDX collection	hg19	paired	NextSeq 500
424M	ARID4A	273	0.52	Missense variant	'21/24	.	29.3	-	Targeted Twist Panel	MURAL Prostate Cancer PDX collection	hg19	paired	NextSeq 500
424M	TP53	366	0.28	Missense variant	'7/11	.	23.1	-	Targeted Twist Panel	MURAL Prostate Cancer PDX collection	hg19	paired	NextSeq 500

No information in Gene expression

No information in Drug dosing Table