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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 167.1R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 19
Average PDX Generation Time (days +/- SEM) 121 ± 13
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304; 33620092
Markers 167.1R
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
167.1R ZNRF3 -1.861 0.551 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R TP53 -0.934 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R SUFU -0.865 1.098 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R SMARCAD1 -0.762 1.180 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R SMAD2 -0.763 1.179 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R SETDB1 0.519 2.866 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R PTEN -0.814 1.138 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R PTEN -0.865 1.098 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R PTEN -24.549 8.150e-08 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R PRPF8 -0.934 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R NCOR1 -0.934 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R MGA -0.923 1.055 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R MBD1 -0.763 1.179 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R CDKN1B -0.840 1.118 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
167.1R APC -1.344 0.788 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 167.1R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3bN0
D'Amico Risk Classification 7
Tumour Volume (in cc) 34.6
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 167
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.2
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 167.1R
Patient Age (binned in 5 year age groups) 55-59
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
167.1R TP53 239 1.0 Missense variant '7/11 . 32 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
167.1R PRLR 679 0.65 Missense variant '10/10 0.0008899 23.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
167.1R DCLK3 697 0.49 Missense variant '4/5 . 25.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
167.1R TSC2 701 0.47 Missense variant '30/42 0.0001343 0.729 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
167.1R CTCF 311 0.27 Missense variant '8/12 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500