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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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PDX model details

PDX ID 27.1A Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 29 (8*)
Average PDX Generation Time (days +/- SEM) 82 ± 8
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304; 30049486
Markers 27.1A Cx
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
27.1A Cx ZFHX3 -0.988 1.008 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx SMAD2 -0.962 1.027 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx SETDB1 0.587 3.003 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx RB1 -28.002 7.440e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx PAX6 -1.028 0.981 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx MGA -0.932 1.048 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx MET 0.585 3.000 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx MBD1 -0.962 1.027 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx KMT2C 0.585 3.000 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx FANCA -0.988 1.008 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx EZH2 0.585 3.000 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx CHD1 -26.929 1.570e-08 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx CDH1 -0.988 1.008 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx BRAF 0.585 3.000 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
27.1A Cx AR -4.026 0.061 GSR MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 27.1A
Sample Site Brain
Sample source Autopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, abiraterone

Patient Information

Patient Number 27
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 42
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 27.1A
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
27.1A Cx PCDH11X 187 1.0 Missense variant '2/7 . 22.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx TH 372 0.61 Start lost '1/14 . 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx TH 372 0.61 Start lost '1/14 . 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx LHFPL3 516 0.53 Missense variant '1/5 . 26.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx SON 395 0.51 Missense variant '3/12 . 25.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx IGF2R 655 0.39 Missense variant '16/48 3.28E-05 24 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx NF1 464 0.28 Stop gained '40/58 . 38 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
27.1A Cx AR — — GSR — — — — Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500