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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 224R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 27
Average PDX Generation Time (days +/- SEM) 75 ± 7
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 224R
AR Y
PSA Y
PSMA Y
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
224R USP7 0.511 2.850 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R U2AF1 0.691 3.230 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R TCERG1 0.734 3.327 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R SMARCAD1 -1.401 0.757 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R PTEN -20.992 9.590e-07 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R PALB2 0.511 2.850 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R MRE11A 0.529 2.885 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R MGA -1.403 0.756 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R GEMIN5 0.734 3.327 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R CHD7 0.654 3.147 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R CHD1 0.835 3.567 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R ATM 0.529 2.885 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 224R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Mixed Adeno & Neuro
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3b
D'Amico Risk Classification 7
Tumour Volume (in cc) 8.0
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 224
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.1
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 224R
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
224R TP53 328 1.0 Missense variant '8/11 . 21.1 Likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R DOT1L 453 0.52 Missense variant '26/28 4.06E-06 29.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R TP63 471 0.46 Missense variant,splice region variant '11/14 7.32E-05 16.64 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R HOXB13 376 0.34 Missense variant '2/2 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R SOX9 236 0.27 Missense variant '3/3 . 23.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R FAM46C 390 0.27 Missense variant '2/2 1.63E-05 24.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500