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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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PDX model details

PDX ID 472M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 10 (5*)
Average PDX Generation Time (days +/- SEM) 51 ± 3
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 472M Cx
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
472M Cx CHD7 0.531 2.891 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx PTEN -2.225 0.428 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx CDH1 -1.290 0.818 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx ZFHX3 -1.290 0.818 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx FANCA -1.290 0.818 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx TP53 -1.210 0.865 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx BRCA1 -1.267 0.831 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx NCOR1 -1.298 0.814 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M Cx RB1 -25.408 4.490e-08 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 472M
Sample Site Left ilium
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel

Patient Information

Patient Number 472
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 630
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 472M
Patient Age (binned in 5 year age groups) 50-54
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
472M Cx SRC 535 0.68 Missense variant '12/14 8.15E-06 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M Cx GPR158 736 0.58 Stop gained '11/11 8.19E-06 36 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M Cx CTNNB1 526 0.57 Missense variant '3/15 4.07E-06 28.6 Pathogenic/likely pathogenic, other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500