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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 373M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 13
Average PDX Generation Time (days +/- SEM) 78 ± 7
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 373M
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
373M MYC 0.559469 2.94745 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M SMAD2 0.888683 3.70297 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M FANCD2 -0.746724 1.19191 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M RAF1 -0.746724 1.19191 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M SETD2 -0.759832 1.18113 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M PIK3R1 -1.63343 0.644642 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M RB1 -1.62166 0.649923 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M CDH1 -0.837756 1.11903 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M ZFHX3 -0.837756 1.11903 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M FANCA -0.837756 1.11903 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
373M TP53 -1.19018 0.876496 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 373M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Mixed Adeno & Neuro
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 373
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 373M
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
373M RB1 19 1.0 missense_variant,splice_region_variant '15/27 . 33 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M TP53 119 0.97 missense_variant '8/11 0 28.8 Conflicting_interpretations_of_pathogenicity Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MAP3K1 62 0.71 inframe_insertion '1/20 0 . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MAP2K2 143 0.59 missense_variant '9/11 . 22 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M ABL1 497 0.51 missense_variant '11/11 0.00013 28.6 not_provided Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M ADAMTS7 68 0.44 missense_variant '7/24 . 26.3 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M MYO5A 254 0.35 missense_variant '15/41 6.50E-05 24.4 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M SOS1 196 0.3 missense_variant '4/24 0.000114 32 Uncertain_significance Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M XPO1 200 0.3 missense_variant '15/25 4.47E-06 34 Likely_pathogenic Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
373M SMO 482 0.28 missense_variant '3/12 0.000111 28.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500