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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.10A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 57 ± 4
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.10A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.10A PIK3CB 1.269 4.821 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A IGF2R 0.559 2.947 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A MYC 1.001 4.003 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A NCOR2 0.574 2.978 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A PRPF8 0.530 2.888 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A SETDB1 0.585 2.999 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A TP53 -28.452 5.450e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CUL3 -0.940 1.042 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CHD1 -0.958 1.029 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A APC -0.958 1.029 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A SUFU -0.954 1.032 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A PAX6 -0.953 1.033 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A USP28 -0.966 1.024 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CDKN1B -0.931 1.049 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A BRCA2 -0.995 1.004 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A RB1 -1.410 0.753 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A MGA -0.969 1.022 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A AXIN1 -0.880 1.087 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CDH1 -0.976 1.016 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ZFHX3 -0.976 1.016 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A FANCA -0.976 1.016 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ZNRF3 -0.963 1.026 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ERBB4 -0.940 1.042 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.10A
Sample Site Left lateral cerebellum
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.10A
Patient Age (binned in 5 year age groups) 65-72
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
435.10A BRCA2 176 0.99 Frameshift variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A SUPV3L1 495 0.67 Missense variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A PRKDC 265 0.55 Missense variant '1/87 . 24.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A IRF4 394 0.51 Missense variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A ATAD2B 273 0.5 Missense variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A TSHR 413 0.49 Missense variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A NTRK2 330 0.48 Missense variant '10/21 . 27.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A NOTCH2 434 0.42 Frameshift variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500