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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.23A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 63 ± 9
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.23A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.23A CTNNB1 0.636 3.108 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CTNNB1 0.540 2.909 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PIK3CB 1.289 4.888 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A IGF2R 0.548 2.923 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A KMT2C 0.540 2.909 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CHD7 0.825 3.543 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MYC 0.577 2.984 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FOXA1 0.707 3.265 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FOXA1 0.493 2.815 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ARID4A 0.612 3.056 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A SETDB1 0.537 2.901 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A TP53 -28.374 5.750e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A RB1 -1.336 0.792 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CUL3 -0.900 1.072 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.928 1.051 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.995 1.003 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.771 1.172 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ZNRF3 -0.971 1.020 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A TP53 -1.116 0.923 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PRPF8 -1.116 0.923 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FANCA -1.160 0.895 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ZFHX3 -0.922 1.056 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CDH1 -1.126 0.916 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MGA -1.011 0.992 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CUL3 -1.086 0.942 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.917 1.059 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.790 1.157 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.973 1.019 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CDKN1B -0.895 1.075 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A USP28 -0.926 1.053 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PAX6 -0.983 1.012 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A SUFU -1.009 0.994 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ERBB4 -0.900 1.072 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CHD1 -0.928 1.051 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A SMARCAD1 -0.840 1.117 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MLH1 -0.966 1.024 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.23A
Sample Site Right posterior temporal lobe
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.23A
Patient Age (binned in 5 year age groups) 65-73
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
435.23A BRCA2 183 1.0 Frameshift variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A SUPV3L1 503 0.67 Missense variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A IRF4 337 0.5 Missense variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A NTRK2 320 0.49 Missense variant '10/21 . 27.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A NOTCH2 382 0.48 Frameshift variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A TSHR 425 0.43 Missense variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A ATAD2B 241 0.43 Missense variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500