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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 373M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 12 (2*)
Average PDX Generation Time (days +/- SEM) 92 ± 8
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 373M Cx
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
373M Cx ERF -7.717 0.010 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx PIK3R1 -1.760 0.591 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx RB1 -1.746 0.596 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx ARID1A -1.744 0.597 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx TP53 -0.794 1.153 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx FANCD2 -0.774 1.169 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx RAF1 -0.774 1.169 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx CDH1 -0.768 1.174 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx ZFHX3 -0.768 1.174 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx FANCA -0.768 1.174 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx AKT3 -0.762 1.180 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx STAB2 0.521 2.870 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx ARID2 0.525 2.877 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx KMT2D 0.525 2.877 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx SMAD2 0.533 2.894 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
373M Cx MBD1 0.533 2.894 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 373M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Mixed Adeno & Neuro
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 373
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 373M
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
373M Cx RB1 49 1.0 Missense variant,splice region variant '15/27 . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx TP53 268 0.99 Missense variant '8/11 0 28.8 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx MAP3K1 73 0.71 Inframe insertion '1/20 0 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx MAP2K2 400 0.68 Missense variant '9/11 . 22 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx ADAMTS7 235 0.5 Missense variant '7/24 . 26.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx ABL1 501 0.47 Missense variant '11/11 0.00013 28.6 Not provided Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx CDKN2B-AS1 346 0.42 Splice donor variant,non coding transcript variant . . 11.78 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx MYO5A 461 0.34 Missense variant '15/41 6.50E-05 24.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx LRP1B 295 0.33 Splice donor variant . . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx XIRP2 447 0.32 Frameshift variant '3/11 0.0004841 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx XPO1 401 0.3 Missense variant '15/25 4.47E-06 34 Likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx SOS1 260 0.3 Missense variant '4/24 0.000114 32 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
373M Cx SHH 508 0.28 Missense variant '3/3 . 4.35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500