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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 374M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 21 (13*)
Average PDX Generation Time (days +/- SEM) 56 ± 4
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 374M Cx
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
374M Cx ZFHX3 -26.976 1.520e-08 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx PTEN -22.993 2.400e-07 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx RB1 -1.277 0.825 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx BRAF 0.528 2.884 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx EZH2 0.528 2.884 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx KMT2C 0.528 2.884 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx MET 0.528 2.884 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx SPEN 0.563 2.954 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx FANCD2 0.578 2.986 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx AXIN2 0.596 3.023 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx PIK3R2 0.708 3.268 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx SETDB1 0.770 3.409 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx AKT3 0.770 3.411 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx MYC 3.582 23.954 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 374M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 374
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 374M
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
374M Cx ERBB4 376 1.0 Missense variant '23/28 . 27 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx TP53 422 0.97 Frameshift variant '5/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx TH 495 0.44 Missense variant '8/14 . 15.88 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx FANCL 604 0.31 Missense variant '1/14 . 25.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx GATA2 594 0.28 Missense variant '3/6 . 21.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx MGAM 847 0.27 Missense variant '16/48 . 23.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500