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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 156R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Renal
Current Generation
(* indicates number of generations grown in Castrate host)
 7
Average PDX Generation Time (days +/- SEM) 269 ± 52
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements.
Pubmed ID 34413304
Markers 156R
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
156R NCOR1 -23.369 1.850e-07 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R PIK3R1 -1.589 0.665 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R CDK12 -0.813 1.139 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R BRCA1 -0.811 1.140 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R NCOR1 -0.783 1.162 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R FANCA -0.778 1.166 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R AKT1 0.565 2.958 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R MET 0.718 3.290 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R BRAF 0.718 3.290 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R EZH2 0.718 3.290 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R KMT2C 0.718 3.290 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R MYC 0.743 3.346 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
156R CHD7 0.750 3.365 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 156R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3b
D'Amico Risk Classification 8
Tumour Volume (in cc) 28.6
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 156
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.8
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 156R
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
156R LOXL1 260 1.0 Missense variant '6/7 9.75E-05 26.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R ATRX 247 1.0 Missense variant '7/35 . 23.4 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R SPOP 229 1.0 Missense variant '6/12 . 24.8 Likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R TP53 183 1.0 Missense variant '7/11 . 25.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R AR 239 0.99 Missense variant '1/8 . 26.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R NEUROG2 400 0.99 Missense variant '2/2 . 25.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R UGT1A4 465 0.65 Missense variant '1/5 . 23.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R SPEN 226 0.43 Missense variant '11/15 0.0003253 24.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R LATS2 192 0.4 Inframe insertion '4/8 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R ARID2 418 0.33 Frameshift variant '15/21 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R GRIN2A 332 0.28 Missense variant '10/14 . 28.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
156R NTRK1 499 0.27 Missense variant '17/17 . 24 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500