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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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PDX model details

PDX ID 387.38A Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 12 (4*)
Average PDX Generation Time (days +/- SEM) 201 ± 35
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 387.38A Cx
AR Y
PSA Y
PSMA Y
NE Y
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
387.38A Cx TP53 -1.697 0.617 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx AXIN2 -1.643 0.640 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx ZFHX3 -1.546 0.685 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx KDM6A 1.449 2.731 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx AKT1 0.647 3.133 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx MLH1 0.665 3.171 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx GNAS 0.693 3.234 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx CTNNB1 0.829 3.552 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx MYC 1.147 4.430 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
387.38A Cx AR 4.041 16.462 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 387.38A
Sample Site Para-tracheal lymph node
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, enzalutamide, lutetium PSMA, pembrolizumab

Patient Information

Patient Number 387
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 387.38A
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
387.38A Cx TP53 93 1.0 Missense variant '6/11 . 24.8 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx CRLF2 271 1.0 Missense variant '6/6 . 9.837 Not provided Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx KMT2C 404 0.71 Missense variant '43/59 4.48E-05 23.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx NOTCH3 413 0.51 Missense variant '25/33 2.22E-05 16.93 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx UGT1A10 403 0.32 Missense variant '1/5 0.0001666 22.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx DPCR1 542 0.29 Stop gained '2/3 . 24.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
387.38A Cx DPCR1 542 0.29 Stop gained '2/3 . 24.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500