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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 394M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9
Average PDX Generation Time (days +/- SEM) 96 ± 11
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 394M
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
394M CHD1 -21.726 5.770e-07 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD1 -9.117 0.004 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PTEN -6.124 0.029 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M RB1 -1.359 0.780 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PALB2 -0.863 1.100 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CDKN1B -0.852 1.108 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CDH1 -0.808 1.143 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M TP53 -0.798 1.150 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PRPF8 -0.798 1.150 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PTEN -0.794 1.154 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M SUFU -0.794 1.154 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M FANCA -0.760 1.181 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M USP7 -0.742 1.195 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M MET 0.499 2.826 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M USP28 0.507 2.842 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M STAB2 0.580 2.990 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M MRE11A 0.646 3.129 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PIK3CB 0.847 3.597 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M KMT2A 0.891 3.708 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PIK3CA 1.129 4.375 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M AR 2.130 4.377 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.177 4.523 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.210 4.627 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.348 5.091 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M AR 2.564 5.913 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 394M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, enzalutamide, navelbine

Patient Information

Patient Number 394
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 394M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
394M TP53 206 1.0 Missense variant '7/11 0 28.8 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M CDKN1B 195 0.92 Frameshift variant '1/3 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M GRIN2A 273 0.45 Missense variant '4/14 . 26.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M SPOP 503 0.42 Inframe deletion '7/12 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500