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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 395M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 8
Average PDX Generation Time (days +/- SEM) 158 ± 14
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 395M
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
395M KEAP1 -1.233 0.851 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M CDK12 -1.221 0.858 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M RB1 -1.149 0.902 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M XPO1 -1.124 0.917 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M ZFHX3 -0.952 1.034 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M PIK3CB 0.526 2.880 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M PIK3CA 0.526 2.880 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M MET 0.573 2.975 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M BRAF 0.573 2.975 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M EZH2 0.573 2.975 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
395M KMT2C 0.573 2.975 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 395M
Sample Site Suprapubic mass
Sample source Surgery
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 395
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 395M
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
395M NOTCH1 554 0.5 Missense variant '34/34 2.91E-05 27.3 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M POMC 495 0.49 Missense variant '3/3 4.07E-06 24.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M JPH2 546 0.49 Missense variant '1/6 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M ZFHX3 105 0.47 Inframe insertion '10/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M CSMD1 534 0.47 Missense variant '14/70 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M KMT2D 460 0.46 Stop gained '9/54 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M MSH6 365 0.43 Missense variant '4/10 8.57E-05 25.7 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M MSH6 370 0.43 Missense variant '4/10 0.0003834 25.5 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M TNXB 303 0.35 Missense variant '10/13 . 32 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M TNXB 303 0.35 Missense variant '10/13 . 32 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
395M FOXA1 416 0.29 Inframe deletion '2/2 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500