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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 305R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 26
Average PDX Generation Time (days +/- SEM) 46 ± 2
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 305R
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
305R RB1 -28.336 5.900e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R PTEN -3.656 0.159 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R PTEN -1.097 0.935 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R SUFU -1.097 0.935 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R TP53 -1.050 0.966 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R CDH1 -1.019 0.987 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R ZFHX3 -1.019 0.987 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R CDKN1B -1.016 0.989 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R ZFHX3 -1.013 0.991 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R FANCA -1.013 0.991 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R RB1 -0.997 1.002 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R BRCA2 -0.987 1.009 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R ZFHX3 -0.827 1.127 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R USP7 0.564 2.958 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
305R MYC 3.069 16.779 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 305R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score 9
Primary Gleason Score 5
Secondary Gleason Score 4
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3bN1
D'Amico Risk Classification 7
Tumour Volume (in cc) 73.4
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 305
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 305R
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
305R TP53 273 1.0 Stop gained '6/11 4.06E-06 36 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R APC 478 0.51 Missense variant '16/16 . 22 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R DST 525 0.5 Missense variant '11/84 . 26.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R GRM7 721 0.49 Missense variant '8/10 . 24.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R MGAM 535 0.47 Missense variant '21/48 . 15.37 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R NF1 215 0.44 Missense variant,splice region variant '7/58 . 25.8 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
305R HGF 361 0.43 Missense variant '18/18 . 24.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500