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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 387.38A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 19
Average PDX Generation Time (days +/- SEM) 57 ± 3
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 387.38A
AR Y
PSA Y
PSMA Y
NE Y
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
387.38A TP53 -1.365 0.777 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A CDKN1B -0.797 1.151 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A FANCA -0.760 1.181 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A AKT1 0.497 2.822 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A MRE11A 0.612 3.056 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A MLH1 0.637 3.109 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A CTNNB1 0.637 3.109 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A U2AF1 0.676 3.196 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A ARID2 0.717 3.288 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A GNAS 0.825 3.542 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A MYC 1.171 4.504 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A KDM6A 1.218 2.326 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A KDM6A 1.589 3.007 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
387.38A AR 4.080 16.907 Gain-High MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 387.38A
Sample Site Para-tracheal lymph node
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, enzalutamide, lutetium PSMA, pembrolizumab

Patient Information

Patient Number 387
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 387.38A
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
387.38A TP53 491 0.97 Missense variant '6/11 . 24.8 Conflicting interpretations of pathogenicity Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
387.38A KMT2C 511 0.78 Missense variant '43/59 4.48E-05 23.2 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
387.38A CRLF2 820 0.76 Missense variant '6/6 . 9.837 Not provided Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
387.38A NOTCH3 114 0.47 Missense variant '25/33 2.22E-05 16.93 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
387.38A DPCR1 628 0.34 Stop gained '2/3 . 24.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
387.38A DPCR1 628 0.34 Stop gained '2/3 . 24.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500