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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 407M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9 (5*)
Average PDX Generation Time (days +/- SEM) 128 ± 30
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 407M Cx
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
407M Cx RB1 -1.99062 0.503261 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx SETD2 -1.06766 0.954184 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx TP53 -1.01445 0.990034 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx NCOR1 -1.01445 0.990034 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx CHD1 -0.994875 1.00356 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx APC -0.994875 1.00356 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx JAK1 -0.885067 1.08292 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx SMAD2 -0.871669 1.09303 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx MBD1 -0.871669 1.09303 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx IGF2R -0.862998 1.09962 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx CDKN2A -0.848417 1.11079 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx GEMIN5 0.561987 2.9526 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx AKT1 0.944023 3.84777 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx KDM6A 1.46993 2.77008 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx MYC 1.65733 6.30864 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M Cx CHD7 1.86914 7.30629 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 407M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, abiraterone, enzalutamide

Patient Information

Patient Number 407
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 407M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
407M Cx SMAD2 230 1.0 stop_gained '11/11 . 42 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx TP53 226 1.0 stop_gained '4/11 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx APC 196 0.95 frameshift_variant '16/16 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx AKT1 645 0.7 missense_variant,splice_region_variant '2/13 4.08E-06 25.9 Pathogenic/Likely_pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx MAST4 529 0.46 missense_variant '2/29 0.0008207 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx NF1 228 0.39 missense_variant '51/58 0.0007889 25.4 Conflicting_interpretations_of_pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx NOTCH3 384 0.31 missense_variant '6/33 0.0003093 24.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx FOXO3 160 0.29 frameshift_variant '2/3 0 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M Cx CACNA1H 540 0.26 missense_variant '10/35 0.0002622 4.878 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500