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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.10A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 57 ± 4
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.10A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.10A SETDB1 0.584638 2.99933 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A PIK3CB 1.26923 4.82066 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A IGF2R 0.559109 2.94672 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A MYC 1.00125 4.00347 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A NCOR2 0.574408 2.97813 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A PRPF8 0.530255 2.88837 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ERBB4 -0.940489 1.04211 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CUL3 -0.940489 1.04211 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CHD1 -0.95841 1.02925 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A APC -0.95841 1.02925 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A SUFU -0.953937 1.03244 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A PAX6 -0.953348 1.03287 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A USP28 -0.96603 1.02383 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CDKN1B -0.93092 1.04905 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A BRCA2 -0.994809 1.0036 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A RB1 -1.4102 0.752519 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A MGA -0.968572 1.02202 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A AXIN1 -0.879616 1.08702 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A CDH1 -0.97645 1.01646 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ZFHX3 -0.97645 1.01646 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A FANCA -0.97645 1.01646 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A ZNRF3 -0.962634 1.02624 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.10A TP53 -28.4523 0.00000000545 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.10A
Sample Site Left lateral cerebellum
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.10A
Patient Age (binned in 5 year age groups) 65-72
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
435.10A BRCA2 176 0.99 frameshift_variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A SUPV3L1 495 0.67 missense_variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A PRKDC 265 0.55 missense_variant '1/87 . 24.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A IRF4 394 0.51 missense_variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A ATAD2B 273 0.5 missense_variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A TSHR 413 0.49 missense_variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A NTRK2 330 0.48 missense_variant '10/21 . 27.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.10A NOTCH2 434 0.42 frameshift_variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500