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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.23A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 63 ± 9
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.23A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.23A SETDB1 0.536677 2.90125 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CTNNB1 0.636117 3.10828 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CTNNB1 0.54037 2.90869 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PIK3CB 1.28924 4.88799 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A IGF2R 0.547639 2.92338 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A KMT2C 0.540403 2.90876 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CHD7 0.824794 3.54256 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MYC 0.577342 2.9842 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FOXA1 0.7072 3.26526 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FOXA1 0.492984 2.81471 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ARID4A 0.611642 3.05599 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CUL3 -0.900111 1.07169 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CUL3 -1.08611 0.942059 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MLH1 -0.965854 1.02395 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A SMARCAD1 -0.840343 1.11702 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CHD1 -0.927911 1.05124 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ERBB4 -0.900111 1.07169 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A SUFU -1.00921 0.993636 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PAX6 -0.983341 1.01161 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A USP28 -0.925694 1.05285 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CDKN1B -0.895345 1.07524 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.972713 1.01909 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.790002 1.15669 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A BRCA2 -0.917148 1.05911 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A RB1 -1.33581 0.792339 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A MGA -1.01148 0.992074 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A CDH1 -1.12598 0.916381 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ZFHX3 -0.921986 1.05556 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A FANCA -1.16017 0.89492 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A PRPF8 -1.11561 0.922992 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A TP53 -1.11561 0.922992 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A ZNRF3 -0.97072 1.0205 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.770629 1.17232 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.995229 1.00331 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A APC -0.927911 1.05124 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.23A TP53 -28.3742 0.00000000575 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.23A
Sample Site Right posterior temporal lobe
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.23A
Patient Age (binned in 5 year age groups) 65-73
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
435.23A BRCA2 183 1.0 frameshift_variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A SUPV3L1 503 0.67 missense_variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A IRF4 337 0.5 missense_variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A NTRK2 320 0.49 missense_variant '10/21 . 27.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A NOTCH2 382 0.48 frameshift_variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A TSHR 425 0.43 missense_variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.23A ATAD2B 241 0.43 missense_variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500