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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 162R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Renal
Current Generation
(* indicates number of generations grown in Castrate host)
 13
Average PDX Generation Time (days +/- SEM) 205 ± 8
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 162R
AR Y
PSA Y
PSMA Y
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
162R AKT3 0.652 3.143 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MET 1.039 4.110 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R BRAF 1.039 4.110 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R EZH2 1.039 4.110 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C 1.039 4.110 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R SETDB1 0.494 2.817 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MYC 0.957 3.884 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R CCND1 1.744 6.702 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MRE11A 0.602 3.037 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R STAB2 0.601 3.033 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R NCOR2 0.565 2.958 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R USP7 0.516 2.860 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C 0.947 3.855 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R ATM -0.990 1.007 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R USP28 -0.990 1.007 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R RB1 -0.973 1.019 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MGA -1.109 0.927 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R CDH1 -1.176 0.885 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R ZFHX3 -0.921 1.057 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R FANCA -1.143 0.905 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C -0.910 1.064 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 162R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score 8
Primary Gleason Score 4
Secondary Gleason Score 4
Tertiary Gleason Score None
ISUP Grade Group 4
Tumour Grade pT3aN0
D'Amico Risk Classification 7
Tumour Volume (in cc) 3.4
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 162
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.8
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 162R
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
162R SETBP1 392 0.48 Missense variant '4/6 . 26.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R XIRP2 524 0.45 Missense variant '9/11 6.52E-05 28.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R NCOR2 522 0.32 Frameshift variant '34/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R FOXA1 396 0.31 Inframe deletion '2/2 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500