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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 369R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9
Average PDX Generation Time (days +/- SEM) 105 ± 9
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 369R
AR Y
PSA Y
PSMA Y
NE Y
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
369R AKT1 -0.930346 1.04946 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R BRCA2 -0.921443 1.05596 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R CDKN1B -0.750197 1.18904 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R KMT2A 0.705253 3.26086 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R PTEN -1.8191 0.566795 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R PTEN -9.83431 0.00219083 homdel MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R RB1 -0.737861 1.19926 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R SUFU -1.8191 0.566795 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R TP53 -0.797269 1.15087 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
369R ZFHX3 -1.06078 0.958746 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 369R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3bN0
D'Amico Risk Classification 7
Tumour Volume (in cc) 13.1
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 369
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.8
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 369R
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
369R TP53 168 0.99 missense_variant '7/11 0 29 Pathogenic Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
369R POMC 188 0.64 missense_variant '3/3 0.000852 25.2 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
369R LRP2 395 0.52 missense_variant '52/79 2.84E-05 22.2 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
369R LRP1B 412 0.46 missense_variant '69/91 . 23.5 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500