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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 452C
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 6
Average PDX Generation Time (days +/- SEM) 87 ± 11
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 452C
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
452C CHD7 0.67073 3.18376 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
452C MDM2 4.34787 40.7258 gain-high MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
452C MYC 0.556691 2.94178 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
452C PTEN -0.975886 1.01686 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
452C SUFU -0.975886 1.01686 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 452C
Sample Site Prostate
Sample source Transurethral resection of the prostate
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection PRRT LuTate and Y-Tate, Octreotide

Patient Information

Patient Number 426/452
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 452C
Patient Age (binned in 5 year age groups) 25-29
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
452C NCOR1 351 0.65 missense_variant '25/46 0.0006336 22.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C BRCA1 631 0.59 missense_variant '10/24 0.0002605 17.67 Benign Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C BRCA1 528 0.59 missense_variant '10/24 0.0002845 0.005 Benign Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C BRCA1 459 0.58 missense_variant '7/24 0.000264 24.7 Benign Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C FOXA1 438 0.54 missense_variant '2/2 4.07E-06 25.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C DICER1 513 0.52 missense_variant '25/29 . 27.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C LATS2 334 0.5 missense_variant '8/8 4.12E-06 25.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C FOXA2 438 0.47 stop_gained '2/2 . 48 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
452C FOXA2 438 0.47 stop_gained '2/2 . 48 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500