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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 201.1A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 42
Average PDX Generation Time (days +/- SEM) 35 ± 2
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304; 30049486
Markers 201.1A
AR Y
PSA Y
PSMA N
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
201.1A CDKN1B -0.954155 1.03229 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A KMT2A 0.816013 3.52107 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A MLH1 -0.817194 1.13509 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A PTEN -2.02003 0.493106 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A PTEN -12.2328 0.000415518 homdel MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A RB1 -16.8488 0.0000169 homdel MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A SUFU -2.02003 0.493106 loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
201.1A ZFHX3 0.819031 3.52844 gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 201.1A
Sample Site Dura
Sample source Autopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 201
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 201.1A
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
201.1A AR 204 1.0 missense_variant '8/8 . 25.3 Pathogenic Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A AR 945 0.99 missense_variant '4/8 . 23.2 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A MLH1 142 0.96 inframe_insertion,splice_region_variant '10/19 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A MLH1 168 0.82 splice_acceptor_variant . . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A CACNA1H 107 0.5 missense_variant '9/35 8.90E-05 5.716 Uncertain_significance Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A TGFBR2 119 0.5 frameshift_variant '4/8 0.0003621 35 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A CTNNB1 346 0.5 missense_variant '3/15 . 29.9 Pathogenic/Likely_pathogenic,_other Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A MSH2 298 0.49 missense_variant '16/16 6.12E-05 27.7 Uncertain_significance Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A KMT2D 1715 0.49 missense_variant '48/54 . 33 Conflicting_interpretations_of_pathogenicity Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A GSK3B 366 0.48 missense_variant '6/12 . 27.4 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A GLI2 368 0.48 missense_variant '14/14 . 24.3 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A SIX3 1013 0.46 frameshift_variant '1/2 0 28.8 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A MUTYH 1218 0.46 missense_variant '13/16 0.0007924 20.7 Conflicting_interpretations_of_pathogenicity Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A KMT2C 208 0.45 stop_gained '36/59 0 40 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A BLM 469 0.45 frameshift_variant '7/22 2.95E-05 . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A GLI2 1572 0.44 missense_variant '4/14 4.06E-06 29.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A AIP 1324 0.44 missense_variant '6/6 . 29.7 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A BRCA2 222 0.42 frameshift_variant '11/28 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A OGDH 139 0.41 frameshift_variant '22/23 . 35 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A SIRT1 42 0.4 frameshift_variant '1/9 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A MSH6 464 0.4 frameshift_variant '4/10 . 24.1 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A TERT 124 0.39 missense_variant '2/16 . 5.144 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A NFE2L1 580 0.38 frameshift_variant '2/6 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A ZFHX3 1418 0.34 frameshift_variant '2/10 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A ASXL1 730 0.34 frameshift_variant '13/13 0.0004861 34 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A BBC3 310 0.34 frameshift_variant '4/4 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
201.1A CTCF 536 0.28 stop_gained '11/12 . 39 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500