Banner
Home
Search by IDs Search by Gene
Browse
Patient Tumour & Clinical details PDX & PDXBiomarker details
View & Update
With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 374M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 21 (13*)
Average PDX Generation Time (days +/- SEM) 56 ± 4
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 374M Cx
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
374M Cx AKT3 0.770036 3.41062 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx AXIN2 0.596173 3.0234 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx BRAF 0.528219 2.8843 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx EZH2 0.528219 2.8843 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx FANCD2 0.578262 2.9861 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx KMT2C 0.528219 2.8843 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx MET 0.528219 2.8843 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx MYC 3.58218 23.9538 gain-high MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx PIK3R2 0.708407 3.268 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx PTEN -22.9933 0.00000024 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx RB1 -1.27739 0.825082 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx SETDB1 0.769504 3.40937 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx SPEN 0.562684 2.95403 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
374M Cx ZFHX3 -26.9761 0.0000000152 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 374M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 374
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 374M
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
374M Cx ERBB4 376 1.0 missense_variant '23/28 . 27 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx TP53 422 0.97 frameshift_variant '5/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx TH 495 0.44 missense_variant '8/14 . 15.88 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx FANCL 604 0.31 missense_variant '1/14 . 25.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx GATA2 594 0.28 missense_variant '3/6 . 21.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
374M Cx MGAM 847 0.27 missense_variant '16/48 . 23.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500