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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary



PDX model details

PDX ID 394M Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9 (4*)
Average PDX Generation Time (days +/- SEM) 132 ± 23
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 394M Cx
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
394M Cx AR 3.296 9.822 Gain-High MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx AXIN2 0.646 3.130 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx CDKN1B -1.201 0.870 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx CHD1 -19.898 2.050e-06 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx CHD7 1.362 5.141 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx KMT2A 0.789 3.456 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx NCOR2 0.516 2.860 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx PALB2 -0.755 1.185 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx PIK3CA 1.109 4.315 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx PIK3CB 1.109 4.315 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx PTEN -8.462 0.006 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx RB1 -1.556 0.680 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx SPOP 0.646 3.130 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M Cx USP28 0.789 3.456 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 394M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, enzalutamide, navelbine

Patient Information

Patient Number 394
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 394M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
394M Cx TP53 229 1.0 Missense variant '7/11 0 28.8 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M Cx CDKN1B 167 0.93 Frameshift variant '1/3 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M Cx GRIN2A 232 0.52 Missense variant '4/14 . 26.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M Cx SPOP 663 0.51 Inframe deletion '7/12 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500