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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 410.51A Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 10 (6*)
Average PDX Generation Time (days +/- SEM) 108 ± 9
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 410.51A Cx
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
410.51A Cx AKT3 1.135 4.392 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx BRAF 0.882 3.687 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx CHD7 0.871 3.657 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx EZH2 0.523 2.875 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx GNAS 0.507 2.843 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx IDH1 0.567 2.963 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx KMT2C 0.523 2.875 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx MET 0.504 2.836 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx MYC 0.860 3.630 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx PIK3CB 0.716 3.284 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx RB1 -1.556 0.680 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx RB1 -1.394 0.761 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
410.51A Cx SETDB1 0.564 2.958 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 410.51A
Sample Site Right lung sub pleural tumour
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 410
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 30
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 410.51A
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
410.51A Cx AKT3 176 0.85 Missense variant '3/14 . 28.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
410.51A Cx GATA3 83 0.49 Missense variant '3/6 8.26E-06 26.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
410.51A Cx ZNF703 200 0.44 Missense variant '1/2 0.0002802 28.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
410.51A Cx CRLF2 115 0.27 Missense variant '6/6 . 9.837 Not provided Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
410.51A Cx ASXL1 250 0.26 Missense variant '12/13 . 26 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500