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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 472M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 20
Average PDX Generation Time (days +/- SEM) 54 ± 7
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 472M
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
472M BRCA1 -0.945 1.039 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CDH1 -1.013 0.991 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CDKN1B -1.041 0.972 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CHD7 0.594 3.020 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M FANCA -1.013 0.991 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M GNAS 0.561 2.950 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M IGF2R 0.506 2.840 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M KEAP1 0.515 2.858 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M MYC 0.494 2.816 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M NCOR1 -1.008 0.995 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PIK3R2 0.515 2.858 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PTEN -1.935 0.523 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PTEN -0.992 1.005 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M RB1 -27.780 8.680e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M SETDB1 0.512 2.852 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M TP53 -1.088 0.941 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M ZFHX3 -1.013 0.991 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 472M
Sample Site Left ilium
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel

Patient Information

Patient Number 472
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 630
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 472M
Patient Age (binned in 5 year age groups) 50-54
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
472M SRC 717 0.66 Missense variant '12/14 8.15E-06 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M GPR158 720 0.58 Stop gained '11/11 8.19E-06 36 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M CTNNB1 614 0.49 Missense variant '3/15 4.07E-06 28.6 Pathogenic/likely pathogenic, other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500