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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 374M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 12
Average PDX Generation Time (days +/- SEM) 94 ± 10
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 374M
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
374M SPEN 0.647 3.131 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M ARID1A 0.647 3.131 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M AKT3 0.839 3.578 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M IDH1 1.043 4.122 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M ERBB4 1.043 4.122 Gain MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M MYC 3.540 23.268 Gain-High MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M RB1 -1.439 0.737 Loss MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M PTEN -8.973 0.004 Homdel MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19
374M ZFHX3 -7.622 0.010 Homdel MURAL Prostate Cancer PDX collection Targeted GARVAN Panel hg19

Clinical Information

Sample Number 374M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT

Patient Information

Patient Number 374
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 374M
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
374M TP53 654 0.96 Frameshift variant '5/11 . . - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
374M TH 225 0.45 Missense variant '8/14 . 15.88 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
374M SPEN 1686 0.39 Missense variant '11/15 3.25E-05 24.6 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
374M ERBB4 788 0.33 Missense variant '23/28 . 27 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
374M GATA2 1039 0.33 Missense variant '3/6 . 21.9 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500
374M FANCL 267 0.29 Missense variant '1/14 . 25.8 - Targeted GARVAN Panel MURAL Prostate Cancer PDX collection hg19 paired Illumina HiSeq 2500