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Patient Tumour & Clinical details PDX & PDXBiomarker details
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Summary

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This process involves analyzing complex genetic data and may take a moment.




PDX model details

PDX ID 407M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9
Average PDX Generation Time (days +/- SEM) 73 ± 6
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 407M
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
407M GEMIN5 0.782 3.438 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M CHD7 1.684 6.428 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M MYC 1.594 6.036 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M AKT1 0.909 3.755 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M JAK1 -0.772 1.172 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M SETD2 -0.844 1.114 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M CHD1 -0.834 1.122 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M APC -0.834 1.122 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M RB1 -1.925 0.527 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M TP53 -0.822 1.131 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M NCOR1 -0.822 1.131 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M SMAD2 -0.780 1.165 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
407M MBD1 -0.780 1.165 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 407M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, abiraterone, enzalutamide

Patient Information

Patient Number 407
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 407M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
407M TP53 249 1.0 Stop gained '4/11 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M SMAD2 199 0.98 Stop gained '11/11 . 42 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M APC 206 0.93 Frameshift variant '16/16 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M AKT1 552 0.64 Missense variant,splice region variant '2/13 4.08E-06 25.9 Pathogenic/likely pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M CACNA1H 347 0.54 Missense variant '10/35 0.0002622 4.878 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M NF1 286 0.49 Missense variant '51/58 0.0007889 25.4 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M MAST4 522 0.48 Missense variant '2/29 0.0008207 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
407M NOTCH3 406 0.32 Missense variant '6/33 0.0003093 24.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500