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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.7A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 57 ± 8
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.7A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.7A CDH1 -1.150 0.901 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A TP53 -28.561 5.050e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A APC -1.022 0.985 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CHD1 -1.022 0.985 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZNRF3 -0.950 1.035 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZNRF3 -1.202 0.869 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A FANCA -1.138 0.909 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZFHX3 -0.892 1.078 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZFHX3 -1.150 0.901 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A PIK3CB 1.128 4.372 Gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A MGA -1.054 0.964 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A RB1 -1.330 0.796 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A BRCA2 -0.986 1.010 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CDKN1B -0.999 1.001 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A PAX6 -0.935 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A SUFU -0.985 1.010 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CUL3 -0.936 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ERBB4 -0.936 1.046 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.7A
Sample Site Front-parietal lobe
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.7A
Patient Age (binned in 5 year age groups) 65-71
This heatmap displays the mutations of curated sequence variants.
Download Plot
The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
435.7A BRCA2 194 0.98 Frameshift variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A SUPV3L1 567 0.63 Missense variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A ATAD2B 295 0.53 Missense variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A TSHR 544 0.5 Missense variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A IRF4 402 0.46 Missense variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A NOTCH2 493 0.43 Frameshift variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A PRKDC 291 0.42 Missense variant '1/87 . 24.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A KMT2C 708 0.27 Stop gained '16/59 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500