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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 365R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Renal
Current Generation
(* indicates number of generations grown in Castrate host)
 8
Average PDX Generation Time (days +/- SEM) 224 ± 25
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 365R
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
365R MYC 0.578995 2.98762 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R CCND1 1.99464 7.97033 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R USP28 0.58509 3.00027 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R KMT2A 0.58509 3.00027 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R CDK12 0.596716 3.02454 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R SPOP 0.545933 2.91993 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R AXIN2 0.545933 2.91993 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R IGF2R -0.952598 1.0334 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R PTEN -1.75233 0.593644 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R SUFU -1.75233 0.593644 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R CDH1 -0.937515 1.04426 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R ZFHX3 -0.937515 1.04426 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R FANCA -0.937515 1.04426 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R PRPF8 -0.927386 1.05162 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R TP53 -0.927386 1.05162 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R NCOR1 -0.927386 1.05162 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R ZNRF3 -0.92942 1.05014 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
365R PTEN -14.4532 0.0000892 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 365R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumour Diagnosis None
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumour Grade pT3aN1
D'Amico Risk Classification 7
Tumour Volume (in cc) 8.6
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 365
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 6.3
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 365R
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
365R TP53 235 1.0 stop_gained '10/11 . 36 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R PRDM2 465 0.53 missense_variant '8/10 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R NR3C1 594 0.52 stop_gained '2/9 . 36 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R CACNA1H 571 0.48 missense_variant '17/35 0.0007575 3.993 Likely_benign Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R SDHA 408 0.47 missense_variant '2/15 0.0004432 22.9 Conflicting_interpretations_of_pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R RYR1 703 0.4 missense_variant '43/106 0.0004264 22.5 Conflicting_interpretations_of_pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
365R ASPM 609 0.39 stop_gained '18/28 2.04E-05 38 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500