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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary

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PDX model details

PDX ID 201.1A Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 61 (30*)
Average PDX Generation Time (days +/- SEM) 39 ± 2
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304; 30049486
Markers 201.1A Cx
AR Y
PSA Y
PSMA Y
NE N
ERG Y
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
201.1A Cx CUL3 -1.025 0.983 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx USP28 -0.901 1.071 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx CDKN1B -1.069 0.953 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx TP53 -0.937 1.044 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx ERF -0.908 1.066 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx CDKN2A -0.997 1.002 Loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx RB1 -28.028 7.310e-09 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
201.1A Cx PTEN -16.819 1.730e-05 Homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 201.1A
Sample Site Dura
Sample source Autopsy
Pathology Tumour Diagnosis Adenocarcinoma
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, abiraterone, enzalutamide

Patient Information

Patient Number 201
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data Yes, subject to ethical review

Patient Tumour Collection (Current Model)
Tumour sample ID 201.1A
Patient Age (binned in 5 year age groups) 70-74
This heatmap displays the mutations of curated sequence variants.
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The Mut plot is not shown
PDX ID Gene Symbol Total Read Depth Alternate Frequency Consequence Exon GnomAD AF CADD PHRED score ClinVar significance Platform Experiments Name Reference Library Type Instrument Type
201.1A Cx ZMYM3 198 1.0 Stop gained '2/25 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AR 280 1.0 Missense variant '4/8 . 23.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AR 236 0.99 Missense variant '8/8 . 25.3 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MLH1 70 0.93 Inframe insertion,splice region variant '10/19 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MLH1 84 0.79 Splice acceptor variant . . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx STAT4 249 0.55 Splice acceptor variant . . 28.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TGFBR2 162 0.54 Frameshift variant '4/8 0.0003621 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ERBB4 228 0.54 Splice donor variant . . 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MUTYH 499 0.54 Missense variant '13/16 0.0007924 20.7 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ARFRP1 348 0.53 Missense variant '7/7 . 29.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx LRP2 584 0.53 Missense variant '25/79 . 25.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 395 0.51 Frameshift variant '25/43 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AXIN2 273 0.51 Frameshift variant '7/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CACNA1H 438 0.5 Missense variant '9/35 8.90E-05 5.716 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SPTA1 321 0.5 Missense variant,splice region variant '4/52 . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TCERG1 330 0.49 Frameshift variant '20/22 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 425 0.49 Splice acceptor variant . . 26.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GSK3B 287 0.49 Missense variant '6/12 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GLI2 387 0.49 Missense variant '14/14 . 24.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GLI2 343 0.48 Missense variant '4/14 4.06E-06 29.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MSH2 304 0.48 Missense variant '16/16 6.12E-05 27.7 Uncertain significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2D 457 0.47 Missense variant '48/54 . 33 Conflicting interpretations of pathogenicity Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx OGDH 563 0.47 Frameshift variant '22/23 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2C 398 0.47 Stop gained '36/59 0 40 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SIX3 289 0.47 Frameshift variant '1/2 0 28.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ARID4A 314 0.47 Frameshift variant '16/24 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BBC3 534 0.47 Frameshift variant '4/4 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MYH14 443 0.46 Missense variant '30/43 . 28 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx XIRP2 338 0.46 Frameshift variant '9/11 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ZFHX3 496 0.46 Frameshift variant '2/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TOP2A 415 0.46 Frameshift variant '34/35 3.31E-05 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ATR 218 0.46 Frameshift variant '20/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx PPP2R1A 507 0.46 Missense variant '4/15 . 27.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx SIRT1 209 0.45 Frameshift variant '1/9 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NCAM1 239 0.45 Frameshift variant '1/19 . 24.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NCOR2 583 0.45 Frameshift variant '29/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AIP 467 0.45 Missense variant '6/6 . 29.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MGA 339 0.44 Splice donor variant . . 25.6 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx AXIN2 481 0.44 Frameshift variant '8/11 0 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BLM 281 0.43 Frameshift variant '7/22 2.95E-05 . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CTNNB1 448 0.43 Missense variant '3/15 . 29.9 Pathogenic/likely pathogenic, other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx TERT 479 0.42 Missense variant '2/16 . 5.144 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx BRCA2 286 0.42 Frameshift variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx CHEK2 367 0.42 Splice donor variant . . 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx FANCE 474 0.41 Frameshift variant '4/10 8.53E-05 22.8 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx MSH6 374 0.41 Frameshift variant '4/10 . 24.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx PARP10 398 0.39 Missense variant,splice region variant '10/11 . 24.3 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx NFE2L1 329 0.39 Frameshift variant '2/6 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx KMT2C 322 0.34 Frameshift variant '38/59 4.07E-05 24 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx ASXL1 559 0.33 Frameshift variant '13/13 0.0004861 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
201.1A Cx GRM7 456 0.27 Frameshift variant '3/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500

PDX ID Treatment1 Dose (mg/kg) Frequency Treatment2 Dose (mg/kg) Frequency Response
201.1A Cx Carboplatin 50 qwk NA NA NA No response
201.1A Cx Talazoparib 0.33 qd Carboplatin 50 qwk No response
201.1A Cx Talazoparib 0.33 qd NA NA NA No response