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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 394M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 9
Average PDX Generation Time (days +/- SEM) 96 ± 11
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 394M
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
394M PIK3CB 0.846714 3.5968 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PIK3CA 1.12939 4.37532 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M MET 0.498595 2.82567 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.21014 4.6272 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.34785 5.09065 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD7 1.17729 4.52303 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M MRE11A 0.645656 3.1289 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M USP28 0.50684 2.84187 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M KMT2A 0.890831 3.70849 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M STAB2 0.580019 2.98974 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M AR 2.56388 5.91296 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M AR 2.12994 4.37699 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PTEN -0.793542 1.15385 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M SUFU -0.793542 1.15385 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CDKN1B -0.851785 1.1082 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M RB1 -1.35882 0.779802 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M USP7 -0.742396 1.19549 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PALB2 -0.862553 1.09996 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CDH1 -0.807688 1.14259 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M FANCA -0.760374 1.18069 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PRPF8 -0.798118 1.1502 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M TP53 -0.798118 1.1502 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD1 -21.7261 0.000000577 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M CHD1 -9.11739 0.00360099 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
394M PTEN -6.12376 0.028681 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 394M
Sample Site Liver
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel, cabazitaxel, enzalutamide, navelbine

Patient Information

Patient Number 394
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) NA
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 394M
Patient Age (binned in 5 year age groups) 75-79
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
394M TP53 206 1.0 missense_variant '7/11 0 28.8 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M CDKN1B 195 0.92 frameshift_variant '1/3 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M GRIN2A 273 0.45 missense_variant '4/14 . 26.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
394M SPOP 503 0.42 inframe_deletion '7/12 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500