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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 435.7A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 4
Average PDX Generation Time (days +/- SEM) 57 ± 8
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 435.7A
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
435.7A PIK3CB 1.12834 4.37214 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ERBB4 -0.935804 1.0455 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CUL3 -0.935804 1.0455 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A SUFU -0.985152 1.01034 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A PAX6 -0.934795 1.04623 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CDKN1B -0.998891 1.00077 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A BRCA2 -0.985743 1.00993 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A RB1 -1.32999 0.795542 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A MGA -1.05353 0.963576 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CDH1 -1.15002 0.901238 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZFHX3 -1.15002 0.901238 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZFHX3 -0.89187 1.07783 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A FANCA -1.13838 0.908539 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZNRF3 -1.20204 0.86932 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A ZNRF3 -0.950229 1.0351 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A CHD1 -1.02172 0.985058 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A APC -1.02172 0.985058 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
435.7A TP53 -28.5615 0.00000000505 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 435.7A
Sample Site Front-parietal lobe
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, carboplatin plus etoposide

Patient Information

Patient Number 435
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 16.2
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 435.7A
Patient Age (binned in 5 year age groups) 65-71
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
435.7A BRCA2 194 0.98 frameshift_variant '11/28 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A SUPV3L1 567 0.63 missense_variant '13/15 . 31 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A ATAD2B 295 0.53 missense_variant '1/28 . 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A TSHR 544 0.5 missense_variant '11/11 . 27.2 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A IRF4 402 0.46 missense_variant '3/9 3.66E-05 21.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A NOTCH2 493 0.43 frameshift_variant '34/34 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A PRKDC 291 0.42 missense_variant '1/87 . 24.9 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
435.7A KMT2C 708 0.27 stop_gained '16/59 . 35 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500