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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 463.55A
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 5
Average PDX Generation Time (days +/- SEM) 102 ± 16
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 463.55A
AR Y
PSA Y
PSMA Y
NE N
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
463.55A CHD7 1.28382 4.86966 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A MYC 1.31074 4.96137 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A SPOP 1.12682 4.36754 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A GNAS 0.90072 3.73399 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A IGF2R -1.67913 0.624542 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A PTEN -0.791374 1.15559 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
463.55A SUFU -0.791374 1.15559 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 463.55A
Sample Site Peritoneal nodule near colon
Sample source Autopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection Radiotherapy, zoladex, docetaxel, enzalutamide, niraparib, cabazitaxel

Patient Information

Patient Number 455/463
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 7.8
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 463.55A
Patient Age (binned in 5 year age groups) 55-59
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
463.55A GPR124 178 1.0 missense_variant '8/19 2.04E-05 26.5 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
463.55A TP53 134 1.0 stop_gained '7/11 . 37 Pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
463.55A RET 179 0.55 missense_variant '14/20 0.0001709 24 Uncertain_significance Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
463.55A ZFHX3 104 0.48 inframe_insertion '10/10 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
463.55A NCOR1 266 0.45 missense_variant '28/46 0.0007429 33 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
463.55A SPTA1 134 0.27 splice_acceptor_variant . . 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500