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Patient Tumour & Clinical details PDX & PDXBiomarker details
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With gene expression Without gene expression Mutation & CNV Plot
Summary



PDX model details

PDX ID 472M
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
 20
Average PDX Generation Time (days +/- SEM) 54 ± 7
Tumour preparation Tumor solid
Tumour Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumour confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 472M
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
472M SETDB1 0.511781 2.85162 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M IGF2R 0.505705 2.83963 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CHD7 0.594417 3.01972 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M MYC 0.493684 2.81607 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M KEAP1 0.515039 2.85807 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PIK3R2 0.515039 2.85807 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M GNAS 0.560716 2.95 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PTEN -0.992376 1.0053 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M PTEN -1.93493 0.523068 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CDKN1B -1.04147 0.971664 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M CDH1 -1.01288 0.991112 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M ZFHX3 -1.01288 0.991112 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M FANCA -1.01288 0.991112 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M TP53 -1.08839 0.940572 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M NCOR1 -1.00759 0.994753 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M BRCA1 -0.944803 1.039 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
472M RB1 -27.7802 0.00000000868 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 472M
Sample Site Left ilium
Sample source Biopsy
Pathology Tumour Diagnosis None
Gleason Score None
Primary Gleason Score None
Secondary Gleason Score None
Tertiary Gleason Score None
ISUP Grade Group
Tumour Grade
D'Amico Risk Classification
Tumour Volume (in cc) 0.0
Treatment Prior to Specimen Collection ADT, docetaxel

Patient Information

Patient Number 472
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 630
Consent to share data

Patient Tumour Collection (Current Model)
Tumour sample ID 472M
Patient Age (binned in 5 year age groups) 50-54
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
472M SRC 717 0.66 missense_variant '12/14 8.15E-06 25.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M GPR158 720 0.58 stop_gained '11/11 8.19E-06 36 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
472M CTNNB1 614 0.49 missense_variant '3/15 4.07E-06 28.6 Pathogenic/Likely_pathogenic,_other Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500