A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 463.58A |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Testosterone supplemented |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
7 |
| Average PDX Generation Time (days +/- SEM) | 67 ± 5 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 463.58A |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | N |
| ERG | N |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 463.58A | CHD7 | 1.5341 | 5.79215 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | SPOP | 1.28725 | 4.88125 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | MYC | 1.12876 | 4.37341 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | KDM6A | 1.03963 | 2.0557 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | AKT1 | 0.767899 | 3.40558 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | STAB2 | 0.565417 | 2.95963 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | GNAS | 0.539147 | 2.90623 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | FOXA1 | 0.520724 | 2.86935 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | NCOR2 | 0.500624 | 2.82965 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | STAB2 | 0.485782 | 2.80069 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | FANCD2 | -0.741822 | 1.19597 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | RAF1 | -0.741822 | 1.19597 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | MSH2 | -0.759986 | 1.181 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | MGA | -0.764349 | 1.17744 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | FANCA | -0.819985 | 1.1329 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | TP53 | -0.82166 | 1.13158 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | CDH1 | -0.826301 | 1.12795 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | KEAP1 | -0.850437 | 1.10923 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | XPO1 | -0.866284 | 1.09712 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | SMARCAD1 | -1.39337 | 0.761349 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | IGF2R | -1.41423 | 0.75042 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | PIK3R1 | -1.47782 | 0.718062 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | CHD1 | -1.47782 | 0.718062 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | APC | -1.47782 | 0.718062 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.58A | SMARCAD1 | -1.49865 | 0.707769 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 463.58A |
|---|---|
| Sample Site | Tumour adjacent to pancreas |
| Sample source | Autopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | Radiotherapy, zoladex, docetaxel, enzalutamide, niraparib, cabazitaxel |
Patient Information
| Patient Number | 455/463 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | 7.8 |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 463.58A |
| Patient Age (binned in 5 year age groups) | 55-59 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 463.58A | GPR124 | 241 | 1.0 | missense_variant | '8/19 | 2.04E-05 | 26.5 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.58A | TP53 | 174 | 1.0 | stop_gained | '7/11 | . | 37 | Pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.58A | NCOR1 | 443 | 0.42 | missense_variant | '28/46 | 0.0007429 | 33 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.58A | ZFHX3 | 132 | 0.41 | inframe_insertion | '10/10 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.58A | SPTA1 | 365 | 0.34 | splice_acceptor_variant | . | . | 34 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table