... A web-based Atlas of Patient-Derived Xenografts of cancer patients:A resource of MURAL PDX data
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PDX model details

PDX ID 162R
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Testosterone supplemented
Graft Site Renal
Current Generation
(* indicates number of generations grown in Castrate host)
 13
Average PDX Generation Time (days +/- SEM) 205 ± 8
Tumor preparation Tumor solid
Tumor Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 162R
AR Y
PSA Y
PSMA Y
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
162R MET 1.03929 4.11043 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C 0.946605 3.85466 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R USP7 0.516235 2.86044 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R NCOR2 0.564571 2.9579 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R STAB2 0.600703 3.03291 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MRE11A 0.602488 3.03667 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R CCND1 1.74449 6.70153 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MYC 0.957382 3.88357 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R SETDB1 0.494023 2.81673 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C 1.03929 4.11043 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R EZH2 1.03929 4.11043 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R BRAF 1.03929 4.11043 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R AKT3 0.652363 3.14348 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R ATM -0.989575 1.00725 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R USP28 -0.989575 1.00725 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R RB1 -0.97255 1.01921 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R MGA -1.10871 0.927417 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R CDH1 -1.17596 0.885178 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R ZFHX3 -0.9207 1.05651 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R FANCA -1.14347 0.905339 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
162R KMT2C -0.909919 1.06443 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 162R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumor Diagnosis Adenocarcinoma
Gleason Score 8
Primary Gleason Score 4
Secondary Gleason Score 4
Tertiary Gleason Score None
ISUP Grade Group 4
Tumor Grade pT3aN0
D'Amico Risk Classification 7
Tumor Volume (in cc) 3.4
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 162
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.8
Consent to share data

Patient Tumor Collection (Current Model)
Tumour sample ID 162R
Patient Age (binned in 5 year age groups) 65-69
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
162R SETBP1 392 0.48 missense_variant '4/6 . 26.7 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R XIRP2 524 0.45 missense_variant '9/11 6.52E-05 28.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R NCOR2 522 0.32 frameshift_variant '34/47 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
162R FOXA1 396 0.31 inframe_deletion '2/2 . . - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500