A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 387.38A Cx |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Castrate |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
12 (4*) |
| Average PDX Generation Time (days +/- SEM) | 201 ± 35 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 387.38A Cx |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | Y |
| ERG | Y |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 387.38A Cx | TP53 | -1.69727 | 0.616738 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | AXIN2 | -1.64309 | 0.64034 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | ZFHX3 | -1.54635 | 0.68475 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | AKT1 | 0.647398 | 3.13268 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | MLH1 | 0.665149 | 3.17146 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | GNAS | 0.693134 | 3.23358 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | CTNNB1 | 0.828734 | 3.55225 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | MYC | 1.1473 | 4.42998 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | KDM6A | 1.4492 | 2.73057 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 387.38A Cx | AR | 4.04104 | 16.4617 | gain-high | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 387.38A |
|---|---|
| Sample Site | Para-tracheal lymph node |
| Sample source | Autopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | ADT, docetaxel, cabazitaxel, enzalutamide, lutetium PSMA, pembrolizumab |
Patient Information
| Patient Number | 387 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | NA |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 387.38A |
| Patient Age (binned in 5 year age groups) | 60-64 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 387.38A Cx | TP53 | 93 | 1.0 | missense_variant | '6/11 | . | 24.8 | Conflicting_interpretations_of_pathogenicity | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | CRLF2 | 271 | 1.0 | missense_variant | '6/6 | . | 9.837 | not_provided | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | KMT2C | 404 | 0.71 | missense_variant | '43/59 | 4.48E-05 | 23.2 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | NOTCH3 | 413 | 0.51 | missense_variant | '25/33 | 2.22E-05 | 16.93 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | UGT1A10 | 403 | 0.32 | missense_variant | '1/5 | 0.0001666 | 22.8 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | DPCR1 | 542 | 0.29 | stop_gained | '2/3 | . | 24.6 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 387.38A Cx | DPCR1 | 542 | 0.29 | stop_gained | '2/3 | . | 24.6 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table