A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 463.55A |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Testosterone supplemented |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
5 |
| Average PDX Generation Time (days +/- SEM) | 102 ± 16 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 463.55A |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | N |
| ERG | N |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 463.55A | IGF2R | -1.67913 | 0.624542 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | PTEN | -0.791374 | 1.15559 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | SUFU | -0.791374 | 1.15559 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | GNAS | 0.90072 | 3.73399 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | SPOP | 1.12682 | 4.36754 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | CHD7 | 1.28382 | 4.86966 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.55A | MYC | 1.31074 | 4.96137 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 463.55A |
|---|---|
| Sample Site | Peritoneal nodule near colon |
| Sample source | Autopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | Radiotherapy, zoladex, docetaxel, enzalutamide, niraparib, cabazitaxel |
Patient Information
| Patient Number | 455/463 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | 7.8 |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 463.55A |
| Patient Age (binned in 5 year age groups) | 55-59 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 463.55A | GPR124 | 178 | 1.0 | missense_variant | '8/19 | 2.04E-05 | 26.5 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.55A | TP53 | 134 | 1.0 | stop_gained | '7/11 | . | 37 | Pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.55A | RET | 179 | 0.55 | missense_variant | '14/20 | 0.0001709 | 24 | Uncertain_significance | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.55A | ZFHX3 | 104 | 0.48 | inframe_insertion | '10/10 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.55A | NCOR1 | 266 | 0.45 | missense_variant | '28/46 | 0.0007429 | 33 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.55A | SPTA1 | 134 | 0.27 | splice_acceptor_variant | . | . | 34 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table