... A web-based Atlas of Patient-Derived Xenografts of cancer patients:A resource of MURAL PDX data



PDX model details

PDX ID 224R Cx
Host Strain(and Source) NSG
Source: Monash University
Host Strain Immune system Humanized NO
Host Type Castrate
Graft Site Subcutaneous
Current Generation
(* indicates number of generations grown in Castrate host)
30 (12*)
Average PDX Generation Time (days +/- SEM) 81 ± 5
Tumor preparation Tumor solid
Tumor Characterization Technology Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed Routine QA every 2-3 passages
Associated meta data
PDX model availability Yes (fixed, frozen or cryopreserved tissue)
Governance restriction for distribution Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID 34413304
Markers 224R Cx
AR N
PSA N
PSMA N
NE Y
ERG N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.

PDX ID Gene Symbol CNV Log2 CNV Copy CNV Call Experiments name Platform Reference genome
224R Cx PTEN -22.7226 0.000000289 homdel MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx MGA -1.43544 0.739468 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx FANCD2 -1.4073 0.754033 loss MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx MRE11A 0.528063 2.88398 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx ATM 0.528063 2.88398 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx USP28 0.528063 2.88398 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx KMT2A 0.528063 2.88398 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx SPEN 0.741883 3.34471 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx TCERG1 0.749303 3.36196 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx GEMIN5 0.749303 3.36196 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx U2AF1 0.827624 3.54952 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx CHD1 1.01788 4.04988 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19
224R Cx CHD7 1.14842 4.43342 gain MURAL Prostate Cancer PDX collection Targeted Twist Panel hg19

Clinical Information

Sample Number 224R
Sample Site Prostate
Sample source Radical prostatectomy
Pathology Tumor Diagnosis Mixed Adeno & Neuro
Gleason Score 9
Primary Gleason Score 4
Secondary Gleason Score 5
Tertiary Gleason Score None
ISUP Grade Group 5
Tumor Grade pT3b
D'Amico Risk Classification 7
Tumor Volume (in cc) 8.0
Treatment Prior to Specimen Collection None

Patient Information

Patient Number 224
Sex Male
Diagnosis Prostate Cancer
PSA at diagnosis (ng/mL) 5.1
Consent to share data

Patient Tumor Collection (Current Model)
Tumour sample ID 224R
Patient Age (binned in 5 year age groups) 60-64
This heatmap displays the mutations of curated sequence variants.
Download The Mut plot is not shown
PDX ID Gene Symbol Depth ALT_FREQ Consequence Exon GnomAD_AF CADD_PHRED Clinvar_clnsig Platform Experiments Name Reference Library Type Instrument Type
224R Cx TP53 311 1.0 missense_variant '8/11 . 21.1 Likely_pathogenic Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx DOT1L 433 0.52 missense_variant '26/28 4.06E-06 29.1 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx CRMP1 353 0.47 splice_donor_variant . . 34 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx HOXB13 385 0.39 missense_variant '2/2 . 27.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx FAM46C 457 0.34 missense_variant '2/2 1.63E-05 24.4 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx GID4 442 0.33 missense_variant '3/6 1.22E-05 32 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500
224R Cx TP63 443 0.3 missense_variant,splice_region_variant '11/14 7.32E-05 16.64 - Targeted Twist Panel MURAL Prostate Cancer PDX collection hg19 paired NextSeq 500

PDX ID Treatment1 Dose (mg/kg) Frequency Treatment2 Dose (mg/kg) Frequency Response
224R Cx Carboplatin 50 qwk NA NA NA Response
224R Cx Talazoparib 0.33 qd Carboplatin 50 qwk Response
224R Cx Talazoparib 0.33 qd NA NA NA Response