PDX model details
PDX ID
272R
Host Strain(and Source)
NSG Source: Monash University
Host Strain Immune system Humanized
NO
Host Type
Testosterone supplemented
Graft Site
Renal
Current Generation (* indicates number of generations grown in Castrate host)
11
Average PDX Generation Time (days +/- SEM)
189 ± 32
Tumor preparation
Tumor solid
Tumor Characterization Technology
Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq
Tumor confirmed not to be of Mouse/EBV origin
Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC
Passage QA performed
Routine QA every 2-3 passages
Associated meta data
PDX model availability
Yes (fixed, frozen)
Governance restriction for distribution
Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements
Pubmed ID
34413304
Markers
272R
AR
Y
PSA
Y
PSMA
Y
NE
Y
ERG
N
This heatmap displays the call type of curated CNVs in the presented samples.
This heatmap displays the call type of CNVs in commonly occurred samples.
This table displays curated CNVs
PDX ID
Gene Symbol
CNV Log2
CNV Copy
CNV Call
Experiments name
Platform
Reference genome
272R
CHD7
1.02403
4.06718
gain
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
272R
MYC
1.02403
4.06718
gain
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
272R
MYC
0.811972
3.51122
gain
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
272R
MSH2
-1.01119
0.992274
loss
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
272R
CDKN1B
-1.01536
0.98941
loss
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
272R
MSH2
-11.1116
0.000903868
homdel
MURAL Prostate Cancer PDX collection
Targeted GARVAN Panel
hg19
Clinical Information
Sample Number
272R
Sample Site
Prostate
Sample source
Radical prostatectomy
Pathology Tumor Diagnosis
Adenocarcinoma
Gleason Score
9
Primary Gleason Score
4
Secondary Gleason Score
5
Tertiary Gleason Score
None
ISUP Grade Group
5
Tumor Grade
pT3bN1
D'Amico Risk Classification
7
Tumor Volume (in cc)
20.2
Treatment Prior to Specimen Collection
None
Patient Information
Patient Number
272
Sex
Male
Diagnosis
Prostate Cancer
PSA at diagnosis (ng/mL)
9.2
Consent to share data
This heatmap displays the mutations of curated sequence variants.
Download
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
PDX ID
Gene Symbol
Depth
ALT_FREQ
Consequence
Exon
GnomAD_AF
CADD_PHRED
Clinvar_clnsig
Platform
Experiments Name
Reference
Library Type
Instrument Type
272R
BCORL1
592
0.94
frameshift_variant
'12/12
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
DMD
106
0.91
frameshift_variant
'40/79
.
34
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
BAX
171
0.8
frameshift_variant
'3/5
0.0001061
23.8
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
PRKDC
725
0.69
missense_variant
'29/87
.
26.6
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
NKX3-1
2365
0.67
inframe_deletion
'2/2
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
LTBP4
243
0.56
missense_variant
'11/34
0.0001098
28
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
MET
455
0.53
stop_gained
'21/21
1.22E-05
38
Uncertain_significance
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
RNF43
1135
0.52
frameshift_variant
'8/9
0
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
WNT4
1047
0.51
missense_variant
'2/5
.
33
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
SOX9
641
0.51
missense_variant
'3/3
.
27.1
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
SMAD2
361
0.51
frameshift_variant
'11/11
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
CYP2D6
411
0.5
missense_variant
'2/9
1.59E-05
29.1
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
OGDH
399
0.5
missense_variant
'7/23
.
33
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
RXRG
303
0.5
missense_variant
'3/10
4.48E-05
25.9
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
LRP2
297
0.5
missense_variant
'46/79
.
24.2
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
NOTCH3
206
0.49
missense_variant
'33/33
1.24E-05
29.1
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
MTOR
399
0.49
missense_variant
'42/58
.
29.8
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
FANCA
995
0.48
missense_variant
'26/43
8.22E-06
23.2
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
FGFR4
1026
0.48
missense_variant
'16/18
.
29.1
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
TRIM33
667
0.48
missense_variant
'11/20
3.66E-05
27
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
SPEN
1306
0.48
frameshift_variant
'11/15
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
CACNA1H
218
0.47
missense_variant
'32/35
1.79E-05
25.5
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
PDGFRB
855
0.47
missense_variant
'13/23
4.18E-06
24.8
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
PBRM1
129
0.47
frameshift_variant
'9/30
0
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
ZFHX3
1259
0.46
frameshift_variant
'9/10
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
CAPN1
263
0.46
missense_variant
'17/21
4.47E-05
32
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
CAPN1
263
0.46
missense_variant
'17/21
4.47E-05
32
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
AKT3
345
0.44
missense_variant
'14/14
.
32
Pathogenic/Likely_pathogenic
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
ZFHX3
1265
0.43
frameshift_variant
'9/10
.
.
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
CACNA1H
175
0.42
missense_variant
'9/35
2.76E-05
22.9
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
272R
ABL1
1551
0.34
missense_variant
'11/11
1.63E-05
29.8
-
Targeted GARVAN Panel
MURAL Prostate Cancer PDX collection
hg19
paired
Illumina HiSeq 2500
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