A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 394M Cx |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Castrate |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
9 (4*) |
| Average PDX Generation Time (days +/- SEM) | 132 ± 23 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 394M Cx |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | N |
| ERG | N |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 394M Cx | AR | 3.29604 | 9.82216 | gain-high | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | AXIN2 | 0.646238 | 3.13016 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | CDKN1B | -1.20059 | 0.870195 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | CHD1 | -19.8985 | 0.00000205 | homdel | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | CHD7 | 1.362 | 5.14083 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | KMT2A | 0.789047 | 3.45587 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | NCOR2 | 0.515982 | 2.85993 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | PALB2 | -0.754516 | 1.18549 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | PIK3CA | 1.10943 | 4.31521 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | PIK3CB | 1.10943 | 4.31521 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | PTEN | -8.46183 | 0.00567238 | homdel | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | RB1 | -1.55623 | 0.680077 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | SPOP | 0.646238 | 3.13016 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 394M Cx | USP28 | 0.789047 | 3.45587 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 394M |
|---|---|
| Sample Site | Liver |
| Sample source | Biopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | ADT, docetaxel, cabazitaxel, enzalutamide, navelbine |
Patient Information
| Patient Number | 394 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | NA |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 394M |
| Patient Age (binned in 5 year age groups) | 75-79 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 394M Cx | TP53 | 229 | 1.0 | missense_variant | '7/11 | 0 | 28.8 | Pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 394M Cx | CDKN1B | 167 | 0.93 | frameshift_variant | '1/3 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 394M Cx | GRIN2A | 232 | 0.52 | missense_variant | '4/14 | . | 26.1 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 394M Cx | SPOP | 663 | 0.51 | inframe_deletion | '7/12 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table