A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 424M |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Testosterone supplemented |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
6 |
| Average PDX Generation Time (days +/- SEM) | 136 ± 38 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 424M |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | N |
| ERG | Y |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 424M | AR | 4.63796 | 24.898 | gain-high | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | BRAF | 0.6762 | 3.19585 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | CDKN1B | -1.58992 | 0.66438 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | CHD7 | 0.979446 | 3.94342 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | EZH2 | 0.6762 | 3.19585 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | FANCD2 | 0.521828 | 2.87155 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | GNAS | 0.535914 | 2.89972 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | MET | 0.689319 | 3.22504 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | MYC | 1.27429 | 4.83759 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | PTEN | -23.8207 | 0.000000135 | homdel | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 424M | RAF1 | 0.521828 | 2.87155 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 424M |
|---|---|
| Sample Site | Lymph node |
| Sample source | Biopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | ADT, zoladex and cosudex |
Patient Information
| Patient Number | 424 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | NA |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 424M |
| Patient Age (binned in 5 year age groups) | 75-79 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 424M | TP53 | 395 | 0.67 | missense_variant | '8/11 | 1.63E-05 | 24 | Pathogenic/Likely_pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 424M | PIK3CA | 322 | 0.62 | missense_variant | '10/21 | 0 | 27.5 | Pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 424M | ARID4A | 273 | 0.52 | missense_variant | '21/24 | . | 29.3 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 424M | TP53 | 366 | 0.28 | missense_variant | '7/11 | . | 23.1 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table