A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 463.45A |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Testosterone supplemented |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
7 |
| Average PDX Generation Time (days +/- SEM) | 62 ± 4 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 463.45A |
|---|---|
| AR | Y |
| PSA | Y |
| PSMA | Y |
| NE | N |
| ERG | N |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 463.45A | BRAF | 0.689479 | 3.2254 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | CDH1 | -0.892144 | 1.07763 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | CHD7 | 1.64054 | 6.23565 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | EZH2 | 0.689479 | 3.2254 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | FANCA | -0.930846 | 1.0491 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | FANCA | -0.775385 | 1.16847 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | FANCD2 | -0.881977 | 1.08525 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | FOXA1 | 0.505725 | 2.83967 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | GNAS | 1.0795 | 4.22661 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | GNAS | 0.846908 | 3.59728 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | IGF2R | -1.55146 | 0.682329 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | KMT2C | 0.689479 | 3.2254 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | MET | 0.689479 | 3.2254 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | MSH2 | -0.85894 | 1.10272 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | MYC | 1.22924 | 4.68887 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | NCOR2 | 0.65559 | 3.15052 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | PTEN | -0.765902 | 1.17617 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | RAF1 | -0.881977 | 1.08525 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | SETD2 | -0.819225 | 1.13349 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | SPOP | 1.16347 | 4.47991 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | STAB2 | 0.706515 | 3.26371 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | SUFU | -0.765902 | 1.17617 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | TP53 | -0.89322 | 1.07682 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 463.45A | XPO1 | -0.920105 | 1.05694 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 463.45A |
|---|---|
| Sample Site | Tumour under diaphragm |
| Sample source | Autopsy |
| Pathology Tumor Diagnosis | None |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | Radiotherapy, zoladex, docetaxel, enzalutamide, niraparib, cabazitaxel |
Patient Information
| Patient Number | 455/463 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | 7.8 |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 463.45A |
| Patient Age (binned in 5 year age groups) | 55-59 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 463.45A | GPR124 | 232 | 1.0 | missense_variant | '8/19 | 2.04E-05 | 26.5 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.45A | TP53 | 127 | 1.0 | stop_gained | '7/11 | . | 37 | Pathogenic | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.45A | NCOR1 | 366 | 0.49 | missense_variant | '28/46 | 0.0007429 | 33 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.45A | ZFHX3 | 110 | 0.47 | inframe_insertion | '10/10 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 463.45A | SPTA1 | 283 | 0.31 | splice_acceptor_variant | . | . | 34 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table