A
web-based Atlas of Patient-Derived Xenografts
of cancer patients:A resource of MURAL PDX data
PDX model details
| PDX ID | 374M Cx |
|---|---|
| Host Strain(and Source) | NSG Source: Monash University |
| Host Strain Immune system Humanized | NO |
| Host Type | Castrate |
| Graft Site | Subcutaneous |
| Current Generation (* indicates number of generations grown in Castrate host) |
21 (13*) |
| Average PDX Generation Time (days +/- SEM) | 56 ± 4 |
| Tumor preparation | Tumor solid |
| Tumor Characterization Technology | Histology, IHC, STR profiling, targeted DNA sequencing, RNAseq |
| Tumor confirmed not to be of Mouse/EBV origin | Yes; negative for CD45 and/or positive for human CK8/18 and/or human mitochondria by IHC |
| Passage QA performed | Routine QA every 2-3 passages |
| Associated meta data | |
| PDX model availability | Yes (fixed, frozen or cryopreserved tissue) |
| Governance restriction for distribution | Available to investigators with appropriate ethics approvals, approved EOI from MURAL committee, and material transfer agreements |
| Pubmed ID | 34413304 |
| Markers | 374M Cx |
|---|---|
| AR | N |
| PSA | N |
| PSMA | N |
| NE | Y |
| ERG | N |
This table displays curated CNVs
| PDX ID | Gene Symbol | CNV Log2 | CNV Copy | CNV Call | Experiments name | Platform | Reference genome |
|---|---|---|---|---|---|---|---|
| 374M Cx | SPEN | 0.562684 | 2.95403 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | SETDB1 | 0.769504 | 3.40937 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | AKT3 | 0.770036 | 3.41062 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | FANCD2 | 0.578262 | 2.9861 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | BRAF | 0.528219 | 2.8843 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | EZH2 | 0.528219 | 2.8843 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | KMT2C | 0.528219 | 2.8843 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | MYC | 3.58218 | 23.9538 | gain-high | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | AXIN2 | 0.596173 | 3.0234 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | PIK3R2 | 0.708407 | 3.268 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | MET | 0.528219 | 2.8843 | gain | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | RB1 | -1.27739 | 0.825082 | loss | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | PTEN | -22.9933 | 0.00000024 | homdel | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
| 374M Cx | ZFHX3 | -26.9761 | 0.0000000152 | homdel | MURAL Prostate Cancer PDX collection | Targeted Twist Panel | hg19 |
Clinical Information
| Sample Number | 374M |
|---|---|
| Sample Site | Liver |
| Sample source | Biopsy |
| Pathology Tumor Diagnosis | Adenocarcinoma |
| Gleason Score | None |
| Primary Gleason Score | None |
| Secondary Gleason Score | None |
| Tertiary Gleason Score | None |
| ISUP Grade Group | |
| Tumor Grade | |
| D'Amico Risk Classification | |
| Tumor Volume (in cc) | 0.0 |
| Treatment Prior to Specimen Collection | ADT |
Patient Information
| Patient Number | 374 |
|---|---|
| Sex | Male |
| Diagnosis | Prostate Cancer |
| PSA at diagnosis (ng/mL) | NA |
| Consent to share data | |
| Patient Tumor Collection (Current Model) | |
|---|---|
| Tumour sample ID | 374M |
| Patient Age (binned in 5 year age groups) | 70-74 |
This table displays curated sequence variants
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
The table can be sorted by any field. However, please note that when you click on a column header to sort, there might be a brief delay
| PDX ID | Gene Symbol | Depth | ALT_FREQ | Consequence | Exon | GnomAD_AF | CADD_PHRED | Clinvar_clnsig | Platform | Experiments Name | Reference | Library Type | Instrument Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 374M Cx | ERBB4 | 376 | 1.0 | missense_variant | '23/28 | . | 27 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 374M Cx | TP53 | 422 | 0.97 | frameshift_variant | '5/11 | . | . | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 374M Cx | TH | 495 | 0.44 | missense_variant | '8/14 | . | 15.88 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 374M Cx | FANCL | 604 | 0.31 | missense_variant | '1/14 | . | 25.8 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 374M Cx | GATA2 | 594 | 0.28 | missense_variant | '3/6 | . | 21.9 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
| 374M Cx | MGAM | 847 | 0.27 | missense_variant | '16/48 | . | 23.9 | - | Targeted Twist Panel | MURAL Prostate Cancer PDX collection | hg19 | paired | NextSeq 500 |
No information in Gene expression
No information in Drug dosing Table